The reason? Dan Zambonini proposes that the prevailing winds in most U.S. cities run westerly, so pollution from industrial smokestacks would blow through the eastern neighborhoods.
While the poorer people moved east, people with money during the industrial era moved westward:
"The massive, unchecked pollution from these early industries would therefore drift eastward, making the air quality much lower in the east end of cities, lowering the desirability (and price) of the housing. Middle classes preferred the cleaner west ends."
FULL STORY: Why are the East of Cities usually Poorer?
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